A glutamyl-tRNA reductase () is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are L-glutamate 1-semialdehyde, NADP<sup>+</sup>, and tRNA(Glu), whereas its 3 products are L-glutamyl-tRNA(Glu), NADPH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming). This enzyme participates in porphyrin and chlorophyll metabolism.