In enzymology, D-arabinose 1-dehydrogenase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are D-arabinose and oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>). Its products are D-arabino-1,4-lactone, reduced NADH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is D-arabinose:NAD<sup>+</sup> 1-oxidoreductase. Other names in common use include NAD<sup>+</sup>-pentose-dehydrogenase, and arabinose(fucose)dehydrogenase.