In enzymology, ureidoglycolate dehydrogenase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are (-)-ureidoglycolic acid and oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>). Its products are oxaluric acid, reduced NADH, and a proton. This enzyme can use the alternative cofactor, nicotinamide adenine dinucleotide phosphate.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is (S)-ureidoglycolate:NAD(P)<sup>+</sup> oxidoreductase. This enzyme participates in purine metabolism.
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .