2,5-didehydrogluconate reductase

In enzymology, 2,5-didehydrogluconate reductase () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are 2-dehydro-D-gluconic acid and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are 2,5-didehydro-D-gluconic acid, reduced NADPH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 2-dehydro-D-gluconate:NADP⁺ 2-oxidoreductase. Other names in common use include 2,5-diketo-D-gluconate reductase, and YqhE reductase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References