Spermidine dehydrogenase () is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are spermidine, an electron acceptor, and water. Its products are 1,3-diaminopropane, 4-aminobutanal, and the correcponding reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donor with other acceptors. The systematic name of this enzyme class is spermidine:acceptor oxidoreductase. This enzyme is also called spermidine:(acceptor) oxidoreductase. This enzyme participates in urea cycle and metabolism of amino groups and beta-alanine metabolism. It has 2 cofactors: flavin adenine dinucleotide, and heme.