Pyruvate dehydrogenase (quinone) (, pyruvate dehydrogenase, pyruvic dehydrogenase, pyruvic (cytochrome b1) dehydrogenase, pyruvate:ubiquinone-8-oxidoreductase, pyruvate oxidase (ambiguous)) is an enzyme with systematic name pyruvate:ubiquinone oxidoreductase. This enzyme catalyses the following chemical reaction
The enzyme converts pyruvic acid to acetic acid by oxidative decarboxylation using ubiquinone as its cofactor. This bacterial enzyme is a flavoprotein located on the inner surface of the cytoplasmic membrane.