In enzymology, 6-hydroxyhexanoate dehydrogenase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are 6-hydroxyhexanoic acid and oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>). Its products are 6-oxohexanoic acid, reduced NADH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is 6-hydroxyhexanoate:NAD<sup>+</sup> oxidoreductase. This enzyme participates in caprolactam degradation.