In enzymology, 15-hydroxyprostaglandin dehydrogenase (NADP<sup>+</sup>) () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are prostaglandin E<sub>1</sub> and oxidised nicotinamide adenine dinucleotide phosphate (NADP<sup>+</sup>). Its products are 15-oxoprostaglandin E<sub>1</sub>, reduced NADPH, and proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is (13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP<sup>+</sup> 15-oxidoreductase. Other names in common use include NADP<sup>+</sup>-dependent 15-hydroxyprostaglandin dehydrogenase, NADP<sup>+</sup>-linked 15-hydroxyprostaglandin dehydrogenase, NADP<sup>+</sup>-specific 15-hydroxyprostaglandin dehydrogenase, type II 15-hydroxyprostaglandin dehydrogenase, and 15-hydroxyprostaglandin dehydrogenase (NADP<sup>+</sup>).
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .