Berberine reductase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are (R)-canadine and oxidised nicotinamide adenine dinucleotide phosphate (NADP<sup>+</sup>). Its products are berberine, reduced NADPH, and two protons.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-tetrahydroberberine:NADP+ oxidoreductase. This enzyme is also called (R)-canadine synthase.