L-pipecolate dehydrogenase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are L-pipecolic acid and an electron acceptor. Its products are (2S)-2,3,4,5-tetrahydropyridine-2-carboxylic acid and the corresponding reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is L-pipecolate:acceptor 1,6-oxidoreductase. This enzyme is also called L-pipecolate:(acceptor) 1,6-oxidoreductase. It participates in lysine degradation. The exact nature of the electron acceptor is unknown, unlike for the enzyme L-pipecolate oxidase, which uses oxygen.