In enzymology, a dTDP-4-dehydro-6-deoxyglucose reductase () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are dTDP-D-fucose and NADP<sup>+</sup>, whereas its 3 products are dTDP-4-dehydro-6-deoxy-D-glucose, NADPH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is dTDP-D-fucose:NADP<sup>+</sup> oxidoreductase. This enzyme is also called dTDP-4-keto-6-deoxyglucose reductase. This enzyme participates in polyketide sugar unit biosynthesis.