N<sup>1</sup>-acetylpolyamine oxidase (, hPAO-1, mPAO, hPAO) is an enzyme with systematic name N<sup>1</sup>-acetylpolyamine:oxygen oxidoreductase (3-acetamidopropanal-forming). This enzyme catalyses the following chemical reaction
(1) N<sup>1</sup>-acetylspermidine + O<sub>2</sub> + H<sub>2</sub>O putrescine + 3-acetamidopropanal + H<sub>2</sub>O<sub>2</sub>
(2) N<sup>1</sup>-acetylspermine + O<sub>2</sub> + H<sub>2</sub>O spermidine + 3-acetamidopropanal + H<sub>2</sub>O<sub>2</sub>
This enzyme also catalyses the reaction:
N<sup>1</sup>,N<sup>12</sup>-diacetylspermine + O<sub>2</sub> + H<sub>2</sub>O N<sub>1</sub>-acetylspermidine + 3-acetamamidopropanal + H<sub>2</sub>O<sub>2</sub>.
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