In enzymology, cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are (1S,2R)-3-phenylcyclohexa-3,5-diene-1,2-diol and oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>). Its products are biphenyl-2,3-diol, reduced NADH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase. This enzyme is also called 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase. This enzyme participates in biphenyl degradation.