In enzymology, a monoprenyl isoflavone epoxidase () is an enzyme that catalyzes the chemical reaction
The 4 substrates of this enzyme are 7-O-methylluteone, NADPH, H<sup>+</sup>, and O<sub>2</sub>, whereas its 3 products are dihydrofurano pyranoisoflavone derivative, NADP<sup>+</sup>, and H<sub>2</sub>O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is 7-O-methylluteone,NADPH:O2 oxidoreductase. Other names in common use include monoprenyl isoflavone monooxygenase, and 7-O-methylluteone:O2 oxidoreductase.