Acetoacetyl-CoA reductase

In enzymology, an acetoacetyl-CoA reductase () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are the (R) isomer of a 3-hydroxyacyl derivative of coenzyme A and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are the corresponding 3-oxoacyl derivative of the coenzyme, reduced NADPH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-3-hydroxyacyl-CoA:NADP⁺ oxidoreductase. Other names in common use include acetoacetyl coenzyme A reductase, hydroxyacyl coenzyme-A dehydrogenase, NADP⁺-linked acetoacetyl CoA reductase, NADPH:acetoacetyl-CoA reductase, D(−)-beta-hydroxybutyryl CoA-NADP⁺ oxidoreductase, short chain beta-ketoacetyl(acetoacetyl)-CoA reductase, beta-ketoacyl-CoA reductase, D-3-hydroxyacyl-CoA reductase, and (R)-3-hydroxyacyl-CoA dehydrogenase. This enzyme participates in butanoate metabolism.

See also

• 3-hydroxyacyl-CoA dehydrogenase operating on the enantiomer of the substrate

References