Terephthalate 1,2-dioxygenase () is an enzyme that catalyzes the chemical reaction
The four substrates of this enzyme are terephthalic acid, reduced nicotinamide adenine dinucleotide (NADH), oxygen, and a proton. Its products are (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylic acid and NAD<sup>+</sup>.
This enzyme is an oxidoreductase that uses molecular oxygen as oxidant and incorporates both its atoms into the starting material. The systematic name of this enzyme class is benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating). Other names in common use include benzene-1,4-dicarboxylate 1,2-dioxygenase, and 1,4-dicarboxybenzoate 1,2-dioxygenase. It is a Rieske protein containing an ironâÂÂsulfur cluster and participates in the metabolism of terephthalic acid.