TRNA-dihydrouridine20 synthase (NAD(P)<sup>+</sup>) (, Dus2p, tRNA-dihydrouridine synthase 2) is an enzyme with systematic name tRNA-5,6-dihydrouracil20:NAD(P)<sup>+</sup> oxidoreductase. This enzyme catalyses the following chemical reaction
This enzyme specifically modifies uracil20 in tRNA.