In enzymology, a nitrite reductase [NAD(P)H] () is an enzyme that catalyzes the chemical reaction
The 4 substrates of this enzyme are ammonium hydroxide, NAD<sup>+</sup>, NADP<sup>+</sup>, and H<sub>2</sub>O, whereas its 4 products are nitrite, NADH, NADPH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ammonium-hydroxide:NAD(P)+ oxidoreductase. Other names in common use include nitrite reductase (reduced nicotinamide adenine dinucleotide, (phosphate)), NADH-nitrite oxidoreductase, NADPH-nitrite reductase, assimilatory nitrite reductase, nitrite reductase [NAD(P)H2], and NAD(P)H2:nitrite oxidoreductase. This enzyme participates in nitrogen metabolism. It has 3 cofactors: FAD, Iron, and Siroheme.
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .