In enzymology, methylglyoxal reductase (NADPH-dependent) () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are (S)-lactaldehyde and oxidised nicotinamide adenine dinucleotide phosphate (NADP<sup>+</sup>). Its products are methylglyoxal, reduced NADPH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is lactaldehyde:NADP<sup>+</sup> oxidoreductase. Other names in common use include lactaldehyde dehydrogenase (NADP<sup>+</sup>), and Gre2.