In enzymology, a CoA-disulfide reductase () is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are CoA, NAD<sup>+</sup>, and NADP<sup>+</sup>, whereas its 4 products are CoA-disulfide, NADH, NADPH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is CoA:NAD(P)+ oxidoreductase. Other names in common use include CoA-disulfide reductase (NADH2), NADH2:CoA-disulfide oxidoreductase, CoA:NAD+ oxidoreductase, CoADR, and coenzyme A disulfide reductase.