In enzymology, tauropine dehydrogenase () is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are tauropine, oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>), and water. Its products are taurine, reduced NADH, pyruvic acid, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N2-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming). This enzyme is also called 2-N-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming).