Malate dehydrogenase (NAD(P)<sup>+</sup>) (, MdH II, NAD(P)<sup>+</sup>-dependent malate dehyrogenase) is an enzyme with systematic name (S)-malate:NAD(P)<sup>+</sup> oxidoreductase. This enzyme catalyses the following chemical reaction:
The enzyme was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyses only the reduction of oxaloacetate, and can use NAD<sup>+</sup> or NADP<sup>+</sup> with similar specific activity. It is different from EC 1.1.1.37 (malate dehydrogenase (NAD<sup>+</sup>)), EC 1.1.1.82 (malate dehydrogenase (NADP<sup>+</sup>)) and EC 1.1.5.4 (malate dehydrogenase (quinone)).