In enzymology, 15-oxoprostaglandin 13-oxidase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are 15-oxodihydroprostaglandin E1 and oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>). Its products are 15-oxoprostaglandin E1, reduced NADH, and a proton. The enzyme can also use nicotinamide adenine dinucleotide phosphate as an alternative cofactor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Delta13-oxidoreductase. Other names in common use include 15-oxo-Delta13-prostaglandin reductase, Delta13-15-ketoprostaglandin reductase, 15-ketoprostaglandin Delta13-reductase, prostaglandin Delta13-reductase, prostaglandin 13-reductase, and 15-ketoprostaglandin Delta13-reductase.
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes , , , and .