Glyoxylate reductase (NADP+)

In enzymology, glyoxylate reductase (NADP⁺) () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are glycolic acid and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are glyoxylic acid, reduced NADPH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is glycolate:NADP⁺ oxidoreductase. Other names in common use include NADPH-glyoxylate reductase, and glyoxylate reductase (NADP⁺). This enzyme participates in pyruvate metabolism and glyoxylate and dicarboxylate metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes , , and .

References