2-Amino-4-deoxychorismate dehydrogenase (, ADIC dehydrogenase, 2-amino-2-deoxyisochorismate dehydrogenase, SgcG) is an enzyme with systematic name (2S)-2-amino-4-deoxychorismate:FMN oxidoreductase. This enzyme catalyses the following chemical reaction
It converts 2-amino-2-deoxyisochorismic acid (1) into 3-(1-carboxyvinyloxy)anthranilic acid (2) by oxidation using flavin mononucleotide (FMN) as its cofactor.
This reaction is part of the biosynthesis of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 from Streptomyces globisporus. The intermediate acid (1) is produced from chorismic acid by the enzyme 2-amino-4-deoxychorismate synthase: