Superoxide reductase is an enzyme that catalyzes the conversion of highly reactive and toxic superoxide (O<sub>2</sub><sup>âÂÂ</sup>) into less toxic hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>):
Hydrogen peroxide in turn is reduced to water by rubrerythrin. The 3 substrates of this enzyme are reduced rubredoxin, superoxide, and H<sup>+</sup>, whereas its two products are rubredoxin and H<sub>2</sub>O<sub>2</sub>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on superoxide as acceptor (only sub-subclass identified to date). The systematic name of this enzyme class is rubredoxin:superoxide oxidoreductase. Other names in common use include neelaredoxin, and desulfoferrodoxin.
, 9 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , and .