Nicotine blue oxidoreductase (, nboR (gene)) is an enzyme with systematic name 3,3'-bipyridine-2,2',5,5',6,6'-hexol:NADP<sup>+</sup> 11-oxidoreductase. This enzyme catalyses the following chemical reaction
The enzyme can use the alternative cofactor, nicotinamide adenine dinucleotide phosphate. It is extracted from the bacterium Arthrobacter nicotinovorans.