In enzymology, (R)-dehydropantoate dehydrogenase () is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are (R)-4-dehydropantoic acid, oxidised nicotinamide adenine dinucleotide (NAD), and water. Its products are (R)-3,3-dimethylmalic acid, reduced NADH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-4-dehydropantoate:NAD+ 4-oxidoreductase. Other names in common use include D-aldopantoate dehydrogenase, D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine, and nucleotide (DPN+) oxidoreductase. This enzyme participates in pantothenate and coa biosynthesis.