Serine 2-dehydrogenase

In enzymology, serine 2-dehydrogenase () is an enzyme that catalyzes the chemical reaction

The three substrates of this enzyme are serine, water, and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are hydroxypyruvic acid, reduced NADH, ammonia, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH₂ group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is L-serine:NAD⁺ 2-oxidoreductase (deaminating). Other names in common use include L-serine:NAD⁺ oxidoreductase (deaminating), and serine dehydrogenase.

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