3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (, paaZ (gene)) is an enzyme with systematic name 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde:NADP<sup>+</sup> oxidoreductase. This enzyme catalyses the following chemical reaction
The enzyme from Escherichia coli is a bifunctional protein that also acts as EC 3.7.1.16, oxepin-CoA hydrolase.