In enzymology, cyclohexane-1,2-diol dehydrogenase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are trans-cyclohexane-1,2-diol and oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>). Its products are 2-hydroxycyclohexan-1-one, reduced NADH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is trans-cyclohexane-1,2-diol:NAD<sup>+</sup> 1-oxidoreductase. This enzyme participates in caprolactam degradation.