In enzymology, (R)-pantolactone dehydrogenase (flavin) () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are (R)-pantolactone and an electron acceptor. Its products are 2-dehydropantolactone and the corresponding reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (R)-pantolactone:acceptor oxidoreductase (flavin-containing). Other names in common use include 2-dehydropantolactone reductase (flavin), 2-dehydropantoyl-lactone reductase (flavin), and (R)-pantoyllactone dehydrogenase (flavin).