In enzymology, quinoline 2-oxidoreductase () is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are quinoline, an electron acceptor, and water. Its products are 2-quinolone and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is quinoline:acceptor 2-oxidoreductase (hydroxylating).
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .