Non-specific polyamine oxidase (, polyamine oxidase, Fms1, AtPAO3) is an enzyme with systematic name polyamine:oxygen oxidoreductase (3-aminopropanal or 3-acetamidopropanal-forming). This enzyme catalyses the following chemical reaction
(1) spermine + O<sub>2</sub> + H<sub>2</sub>O spermidine + 3-aminopropanal + H<sub>2</sub>O<sub>2</sub>
(2) spermidine + O<sub>2</sub> + H<sub>2</sub>O putrescine + 3-aminopropanal + H<sub>2</sub>O<sub>2</sub>
(3) N<sup>1</sup>-acetylspermine + O<sub>2</sub> + H<sub>2</sub>O spermidine + 3-acetamidopropanal + H<sub>2</sub>O<sub>2</sub>
(4) N<sup>1</sup>-acetylspermidine + O<sub>2</sub> + H<sub>2</sub>O putrescine + 3-acetamidopropanal + H<sub>2</sub>O<sub>2</sub>
This enzyme is flavoprotein (FAD).
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