Alanine dehydrogenase

Alanine dehydrogenase () is an enzyme that catalyzes the chemical reaction

The three substrates of this enzyme are alanine, water, and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are pyruvic acid, reduced NADH, ammonia, and a proton.

This enzyme participates in taurine and hypotaurine metabolism and reductive carboxylate cycle ( fixation).

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH₂ group of donors with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is L-alanine:NAD⁺ oxidoreductase (deaminating). Other names in common use include AlaDH, L-alanine dehydrogenase, NAD⁺-linked alanine dehydrogenase, alpha-alanine dehydrogenase, NAD⁺-dependent alanine dehydrogenase, alanine oxidoreductase, and NADH-dependent alanine dehydrogenase. T

Structure

Alanine dehydrogenase contains both a N-terminus and C-terminus domains.

References