In enzymology, indolepyruvate ferredoxin oxidoreductase () is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are indole-3-pyruvic acid, coenzyme A, and oxidized ferredoxin. Its products are S-2-(indol-3-yl)acetyl-CoA, carbon dioxide, and reduced ferredoxin.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is 3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole-acetylating). Other names in common use include 3-(indol-3-yl)pyruvate synthase (ferredoxin), and IOR.