Mannitol 2-dehydrogenase (NADP+)

In enzymology, mannitol 2-dehydrogenase (NADP⁺) () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are D-mannitol and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are D-fructose (shown in its open-chain form), reduced NADPH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-mannitol:NADP⁺ 2-oxidoreductase. This enzyme is also called mannitol 2-dehydrogenase (NADP⁺). This enzyme participates in fructose and mannose metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References