Testosterone 17beta-dehydrogenase

In enzymology, a testosterone 17beta-dehydrogenase is an enzyme that catalyzes the interconversion of testosterone and androstenedione.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor.

Names

The systematic name of this enzyme class is 17beta-hydroxysteroid:NAD⁺ 17-oxidoreductase. Other names in common use include 17-ketoreductase and 17beta-HSD. This enzyme participates in androgen and estrogen metabolism.

Variants

There are two variants of the enzyme, one that uses NADP⁺ as cofactor, and one that uses NAD⁺ instead.

NAD⁺

This variant of testosterone 17beta-dehydrogenase () uses the cofactor oxidised nicotinamide adenine dinucleotide.

NADP⁺

This variant of testosterone 17beta-dehydrogenase () uses the cofactor oxidised nicotinamide adenine dinucleotide phosphate.

See also

• Testosterone glucuronide

References

External links

• Testosterone Enhancement