Valine dehydrogenase (NADP+)

In enzymology, valine dehydrogenase (NADP⁺) () is an enzyme that catalyzes the chemical reaction

The three substrates of this enzyme are L-valine, water, and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are α-ketoisovaleric acid, reduced NADPH, ammonia, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH₂ group of donors with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is L-valine:NADP⁺ oxidoreductase (deaminating). Other names in common use include valine dehydrogenase (nicotinamide adenine dinucleotide phosphate), and valine dehydrogenase (NADP⁺).

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