Pantoate 4-dehydrogenase

In enzymology, pantoate 4-dehydrogenase () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are (R)-pantoic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are (R)-4-dehydropantoic acid, reduced NADH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-pantoate:NAD⁺ 4-oxidoreductase. Other names in common use include pantoate dehydrogenase, pantothenase, and D-pantoate:NAD⁺ 4-oxidoreductase. This enzyme participates in pantothenate and coa biosynthesis.

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