Hydroxycyclohexanecarboxylate dehydrogenase

In enzymology, hydroxycyclohexanecarboxylate dehydrogenase () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylic acid, reduced NADH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD⁺ 3-oxidoreductase. Other names in common use include dihydroxycyclohexanecarboxylate dehydrogenase, and (−)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD⁺ oxidoreductase.

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