2-dehydropantolactone reductase (A-specific)

In enzymology, 2-dehydropantolactone reductase (A-specific) () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are (R)-pantolactone and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are 2-dehydropantolactone, reduced NADPH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-pantolactone:NADP⁺ oxidoreductase (A-specific). Other names in common use include 2-oxopantoyl lactone reductase, ketopantoyl lactone reductase, 2-ketopantoyl lactone reductase, and 2-dehydropantoyl-lactone reductase (A-specific).

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