(R)-limonene 6-monooxygenase () is an enzyme that catalyzes the chemical reaction
The four substrates of this enzyme are (+)-(R)-limonene, reduced nicotinamide adenine dinucleotide phosphate (NADPH), oxygen, and a proton. Its products are (+)-trans-carveol, oxidised NADP, and water. This enzyme is a cytochrome P450 protein containing heme. This oxidoreductase, which uses molecular oxygen as oxidant, is in a group with systematic name (R)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating). Other names in common use include (+)-limonene-6-hydroxylase, and (+)-limonene 6-monooxygenase. It is part of the biosynthesis pathway to (+)-carvone in caraway.