3beta-hydroxy-5alpha-steroid dehydrogenase

In enzymology, 3β-hydroxy-5α-steroid dehydrogenase () is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are isopregnanolone and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are 5α-dihydroprogesterone, reduced NADPH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 3β-hydroxy-5α-steroid:NADP⁺ 3-oxidoreductase.

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