Epi-isozizaene 5-monooxygenase (, CYP170A1) is an enzyme with systematic name (+)-epi-isozizaene,NADPH:oxygen oxidoreductase (5-hydroxylating). This enzyme catalyses the following chemical reaction
(+)-epi-isozizaene + 2 NADPH + 2 H<sup>+</sup> + 2 O<sub>2</sub> albaflavenone + 2 NADP<sup>+</sup> + 3 H<sub>2</sub>O (overall reaction)
(1a) (+)-epi-isozizaene + NADPH + H<sup>+</sup> + O<sub>2</sub> (5S)-albaflavenol + NADP<sup>+</sup> + H<sub>2</sub>O
(1b) (5S)-albaflavenol + NADPH + H<sup>+</sup> + O<sub>2</sub> albaflavenone + NADP<sup>+</sup> + 2 H<sub>2</sub>O
(2a) (+)-epi-isozizaene + NADPH + H<sup>+</sup> + O<sub>2</sub> (5R)-albaflavenol + NADP<sup>+</sup> + H<sub>2</sub>O
(2b) (5R)-albaflavenol + NADPH + H<sup>+</sup> + O<sub>2</sub> albaflavenone + NADP<sup>+</sup> + 2 H<sub>2</sub>O
This cytochrome P450 enzyme is purified from bacterium Streptomyces coelicolor.
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