2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase (, 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP<sup>+</sup> oxidoreductase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase, 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase, LigC, ProD) is an enzyme with systematic name 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal:NADP<sup>+</sup> 2-oxidoreductase. This enzyme catalyses the following chemical reaction:
Unsubstituted aliphatic or aromatic aldehydes or glucose cannot serve as substrate of this enzyme.