Malate dehydrogenase (oxaloacetate-decarboxylating)

In enzymology, a malate dehydrogenase (oxaloacetate-decarboxylating) () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are (S)-malic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are pyruvic acid, carbon dioxide, and reduced NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (S)-malate:NAD⁺ oxidoreductase (oxaloacetate-decarboxylating). Other names in common use include malic enzyme, pyruvic-malic carboxylase, NAD⁺-specific malic enzyme, NAD⁺-malic enzyme, and NAD⁺-linked malic enzyme. This enzyme participates in pyruvate metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , and .

See also

• ME2 (gene)
• Malate dehydrogenase (decarboxylating) which performs the same reaction

References