In enzymology, a hydrogen dehydrogenase (NADP+) () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are H<sub>2</sub> and NADP<sup>+</sup>, whereas its two products are H<sup>+</sup> and NADPH.
This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is hydrogen:NADP+ oxidoreductase. Other names in common use include NADP+-linked hydrogenase, NADP+-reducing hydrogenase, hydrogen dehydrogenase (NADP+), and simply hydrogenase (which is ambiguous).
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .