In enzymology, apiose 1-reductase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are D-apiitol and oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>). Its products are D-apiose, reduced NADH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is D-apiitol:NAD<sup>+</sup> 1-oxidoreductase. Other names in common use include D-apiose reductase, and D-apiitol reductase.