(2R)-3-sulfolactate dehydrogenase (NADP<sup>+</sup>) (, (R)-sulfolactate:NADP<sup>+</sup> oxidoreductase, L-sulfolactate dehydrogenase, (R)-sulfolactate dehydrogenase, ComC) is an enzyme with systematic name (2R)-3-sulfolactate:NADP<sup>+</sup> oxidoreductase. It catalyses the following chemical reaction:
The enzyme from the bacterium Chromohalobacter salexigens can only utilize NADP<sup>+</sup>.